Active Research Projects 

For more information on any our projects contact us at 405-271-7848 or

Group Meeting

Tobacco Treatment Research Program (TTRP)


PI: Darla Kendzor 

The TTRP provides treatment for tobacco dependence free of charge to the public. The clinic functions as an observational research study and prospective data registry where participants are followed for 27 weeks post-enrollment. The TTRP offers weekly group and individual counseling and support sessions, as well as nicotine replacement therapy (NRT) and/or other pharmacological treatments at no cost to those who qualify. 

Man Trying App

Prevail II


PI: Darla Kendzor 

This NIH funded R01 clinical trial compares a standard smoking cessation program (counseling & medication) to standard care plus small financial incentives for verified smoking abstinence. Another goal of the study is to use in person and smartphone based assessments to identify predictors of successful smoking cessation.

Mobile Phone



PIs: Michael Businelle & Jennifer Reingle Gonzalez

This 3-armed NIH R01 is a randomized clinical trial that will use an innovative smartphone application to identify and address barriers that prevent recently incarcerated homeless adults from obtaining available case management, crisis management, substance abuse, and mental health services. For study updates, visit the study's ResearchGate page here.

holding phones



PI: Darla Kendzor 

The purpose of this NIH funded R01 Supplement is to develop a fully automated mobile phone-based approach that allows disadvantaged populations to remotely benefit from smoking cessation treatments that offer financial incentives for smoking cessation.

Smart Phone


PI: Michael Businelle  

This pilot study (N=150) is a 3-armed randomized controlled smoking cessation induction trial that will determine the initial utility of a novel smartphone based intervention compared with an attention control group among smokers who are not ready to quit. 

Woman Holding a Mobile Phone

Anxiety Sensitivity: M-ICART 

PIs: Michael Businelle, Michael Zvolensky, & Julia Buckner

The purpose of this pilot project is to translate our previously tested Integrated Cannabis and Anxiety Reduction Treatment [ICART] into a novel, mobile intervention for Cannabis Use Disorders. 

Mobile Phone

Smart-T Alcohol

PIs: Michael Businelle & Scott Walters 

This 2 phase NIH Funded R34 aims to develop and test a “just in time” adaptive intervention to reduce alcohol use in homeless men and women. Phase I utilizes smartphones and passive sensing technologies to monitor geolocation, psychosocial variables (e.g., stress, affect, urge to drink), and alcohol use (SCRAM). Phase II will use this information to provide tailored treatment messages that anticipate and intervene to prevent drinking and heavy drinking. For more information, visit the study's ResearchGate page here.

Research Projects Starting Soon

Smart-T 3

PI: Michael Businelle

This NCI R01 randomized clinical trial (N=450) will compare the longer-term effects of the Smart-T smoking cessation app with the free and publically available NCI QuitGuide smoking cessation app (Aim 1). The second aim of the proposed study will determine if Smart-T messages that are tailored to address key smoking lapse risk variables in real-time (i.e., urge, stress, cigarette availability, cessation motivation) reduce participant ratings of these lapse risk variables compared with similar situations that do not receive this tailored content (QuitGuide group). For more information, visit the study's ResearchGate page here.


PI: Darla Kendzor & Emily Hébert

This pilot study will compare the effectiveness of combination varenicline and oral nicotine  replacement therapy versus varenicline alone for smoking cessation. In addition, it will examine the effect of medication reminders on pharmacotherapy adherence and cessation. 

Smart Path

PI: Darla Kendzor

The first aim of this study is to evaluate the feasibility and efficacy of a “real-time” smartphone intervention that works in conjunction with a wearable activity monitoring device to reduce sedentary time via smartphone prompts during prolonged sedentary bouts. The second aim is to identify treatment mechanisms and contextual factors associated with sedentary behavior using traditional and ecological momentary assessment (EMA) approaches. The third aim is to compare the physical activity data collected via the activity band with the data collected with two different kinds of objective physical activity measurement tools.

Smoking Cessation for American Indians with Diabetes 

​Investigators: Jennifer Vidrine, Darla Kendzor, Damon Vidrine, Michael Businelle 

The purpose of this pilot study is to identify factors that predict smoking lapse among smokers who attend a Choctaw Nation Hospital Diabetes Clinic.

Completed Research Projects


PI: Michael Businelle

The primary long-term objective of this research is to reduce smoking relapse through the use of automated mobile smoking cessation interventions that tailor content in real-time based upon currently present symptoms. The primary short-term objective of this pilot study is to determine the initial utility of a novel smartphone based smoking cessation intervention compared with standard in-person smoking cessation clinic care and a free smoking cessation application. For study updates, visit the study's ResearchGate page here.

Anxiety Sensitivity: MASP

PI: Michael Businelle & Michael Zvolensky 

The purpose of this pilot study is to feasibility test a novel, mobile intervention for smokers with high anxiety sensitivity (AS). This Mobile Anxiety Sensitivity Program for Smoking (MASP) integrates interoceptive exposure, emotion regulation, cognitive restructuring, and psychoeducation exercises developed from our past work in conjunction with standard smoking cessation strategies and nicotine replacement therapy. 

​Advance II

PI: Michael Businelle

The primary objective of this study is to gain a better understanding of the prevalence of physical and mental health issues among homeless adults in Oklahoma City. The secondary objective is to identify risk and protective factors that have an impact on health behavior and health behavior change in this understudied and underserved population. This information will improve understanding of the health needs of this marginalized group and will provide guidance to our future intervention work with homeless Oklahomans. For more information, visit the study's ResearchGate study page here.